Ciproquin 250 mg Tablet (Ciprofloxacin)

Ciproquin 250 mg is an oral antibiotic that contains ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, repair, and recombination. This inhibition leads to bacterial cell death, making ciprofloxacin effective against many Gram-negative and some Gram-positive bacteria.

Indications

• Urinary tract infections (UTIs)

• Respiratory tract infections (bronchitis, pneumonia)

• Skin and soft tissue infections

• Gastrointestinal infections, including infectious diarrhea

• Bone and joint infections

• Certain sexually transmitted infections

• Prophylaxis and treatment of anthrax exposure

Dosage and Administration

• Typical adult dose: 250 mg every 12 hours (may vary depending on infection severity and physician guidance)

• Tablets should be taken with plenty of water, with or without food

• Avoid taking with dairy products or calcium-fortified juices alone as they may reduce absorption

• Complete the full prescribed course to prevent resistance

Pharmacokinetics

• Well absorbed orally, with peak plasma concentrations reached within 1-2 hours

• Metabolized partially by the liver and eliminated mainly via the kidneys

• Half-life approximately 4 hours

Side Effects

Common:

• Nausea

• Diarrhea

• Dizziness

• Headache

• Abdominal discomfort

Serious (less common):

• Tendonitis and tendon rupture (especially in elderly or corticosteroid users)

• Photosensitivity reactions

• Peripheral neuropathy

• Clostridium difficile-associated diarrhea

• Allergic reactions

Contraindications

• Hypersensitivity to ciprofloxacin or other quinolones

• Tendon disorders related to quinolone therapy

• Concurrent use with tizanidine

• Children and adolescents (unless benefits outweigh risks)

Precautions

• Use cautiously in patients with a history of seizures or CNS disorders

• Avoid excessive exposure to sunlight or UV light due to photosensitivity risk

• Not recommended during pregnancy and breastfeeding unless absolutely necessary

• Adjust dosage in renal impairment

Drug Interactions

• May interact with antacids, sucralfate, iron supplements, and multivitamins containing magnesium or aluminum (reduce ciprofloxacin absorption)

• Can increase plasma levels of theophylline, warfarin, and caffeine

• Avoid concurrent use with corticosteroids due to increased tendon rupture risk

Storage

• Store below 30°C in a dry place

• Keep out of reach of children

Ciproquin 250 mg is a potent and versatile antibiotic ideal for treating various infections. However, it should be used responsibly and only under medical supervision to avoid resistance and adverse effects.