Ketoropack 10 mg Tablet (Ketorolac Tromethamine)

Ketoropack 10 mg is a prescription nonsteroidal anti-inflammatory drug (NSAID) containing ketorolac tromethamine. It is primarily used for the short-term treatment of moderate to severe pain, especially post-operative pain, and acute musculoskeletal injuries. It is known for its potent analgesic (pain-relieving) effect, comparable to low-dose opioids, without the risk of dependence.

Mechanism of Action

Ketorolac works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the synthesis of prostaglandins—chemicals that cause inflammation, pain, and fever. By blocking prostaglandin production, Ketoropack reduces inflammation and provides significant pain relief.

Indications

• Post-operative pain

• Acute musculoskeletal pain (e.g., sprains, strains)

• Renal colic (pain from kidney stones)

• Short-term treatment of moderate to severe pain in adults

Note: Not indicated for chronic pain, mild pain, or long-term therapy.

Dosage and Administration

• Typical adult dose: 10 mg orally every 4 to 6 hours as needed

• Maximum daily dose: 40 mg

• Duration of therapy should not exceed 5 days, including all dosage forms (oral, IV, IM)

• To be taken with food or a full glass of water to reduce stomach upset

Common Side Effects

• Nausea

• Abdominal pain

• Headache

• Drowsiness

• Indigestion

Serious Side Effects (Rare)

• Gastrointestinal bleeding or ulcers

• Kidney dysfunction

• Increased risk of cardiovascular events (e.g., heart attack, stroke)

• Allergic reactions (rash, itching, swelling)

Contraindications

• History of peptic ulcer or GI bleeding

• Severe renal impairment

• Confirmed or suspected cerebrovascular bleeding

• Concurrent use with other NSAIDs or anticoagulants

• Pregnancy (especially third trimester) and breastfeeding

Precautions

• Not recommended for use in children

• Caution in elderly patients and those with cardiovascular, kidney, or liver issues

• Avoid alcohol and smoking during treatment, as they may increase GI side effect risk

• Should not be used before or during major surgery due to bleeding risk

Drug Interactions

• Increased risk of bleeding with warfarin, aspirin, or other NSAIDs

• May reduce the effectiveness of antihypertensive drugs

• Risk of kidney damage when used with diuretics or ACE inhibitors

Storage

• Store at room temperature below 30°C

• Keep in original packaging, away from moisture and heat

• Keep out of reach of children

Ketoropack 10 mg offers strong pain relief for short-term use in adults and is considered a valuable alternative to opioid analgesics in specific clinical scenarios. However, due to its potential for serious side effects, it should be used strictly under medical supervision.